To develop 3D bioPRINTed osteoinductive constructs that deliver CHEMOtherapeutics within large bone defects that are surgically created when removing bone tumours. Utilizing evolutionary interactions to limit multidrug resistance, A potent Micro-RNA therapeutic for nonalcoholic fatty liver disease (NAFLD), Amyotrophic Lateral Sclerosis from a cortical perspective: towards alternative therapeutic strategies, Cerebellar circuit mechanisms of coordinated locomotion in mice, Preclinical development of squalenic acid and gemcitabine squalene nanomedicine, Nano-diamond tracers for MRI molecular imaging, Development of a ncRNA DNA Methylation Kit for the Diagnosis of Cancer of Unknown Primary, COLOStage : A new prognosis test for the prediction of metastasis in Colorectal Cancer and Hepatocellular Carcinoma, Exploring the Potential for Therapeutic Lineage Reprogramming of Diabetes, Bringing CItizens, Models and Data together in Participatory, Interactive SociaL EXploratories, Zinc finger gene therapy in the brain for treating Huntington's disease. Enhanced brown adipose tissue activity using nanotechnology approaches, BIaxial STRETCHing of PLLA-WS2 nanocomposites FOR thinner and stronger BIOMEDical scaffolds, Linking excellence in biomedical knowledge and computational intelligence research for personalized management of CVD within PHC, Rise of scientific excellence and collaboration for implementing personalised medicine in Estonia, TWINNING for a Comprehensive Clinical Centre for the Diagnosis and Treatment of Parkinson's Disease, Towards outstanding research and training in tumour biology at IMM, Immunomodulatory effects of sustained pantethine release in inflammatory diseases, Cerenkov Imaging for Surgical Margin Assessment, Continuous Regional Analysis Device for neonate Lung, New approaches to characterise Schistosoma mansoni infections persisting despite mass drug administration, A mathematical platform for Abdominal Aortic Aneurism risk assessment and surgical planning, Simulation Modeling of coronary ARTery disease: a tool for clinical decision support, Clinical development of a dendritic-cell vaccine therapy for acute myeloid leukaemia, Regulation of lymphocyte biology by ubiquitin and ubiquitin like modifiers, Preventing and mitigating farmed bivalve diseases, Mechanisms of protein translocation in ER-associated protein degradation and the related protein import into the apicoplast of Plasmodium falciparum, PERSONALIZED ENGINE FOR CANCER INTEGRATIVE STUDY AND EVALUATION, A Cardiomyocyte Workout:Using Dielectric Elastomer Actuators for Mechanical Stimulation of in-vitro Cells, MAINTRAC-Auto: Automatization and validation of a liquid biopsy assay “Maintrac-AUTO CTC-analyser” for predictive real time monitoring and success control of solid tumor cancer therapy, Chemical biology approaches to unraveling the histone code, Physical Activity, Inflammation and Respiratory health: an integrative analysis of biological, behavioural and environmental determinants, Innovative, easily applicable vaccine for poultry industry against five Salmonella serovars: Enteritidis, Typhimurium, Hadar, Virchow and Infantis – SAL ETHVI, Magnetic resonance imaging platform for probing fat microstructure. Integration and analysis of heterogeneous big data for precision medicine and suggested treatments for different types of patients. Exploring Healing Remedies through Dental Calculus Analysis, Coherent Back-Lasing from Atmospheric Insects, Visualizing Death Inducing Protein Complexes, Investigation into the Molecular Mechanisms Underlying NEmatode recognition by the Ma resistance protein in perennial plum roots, Adaptive Immunity in Human Atherosclerosis: Understanding its Cellular Basis to Define Novel Immunomodulatory Therapies, Non-biased fluorescent dyes as markers of drugs for optical in cellulo and in vivo imaging, Individualised and Equitable Care of Type 2 Diabetes, Molecular Structure and Engineering of Synaptic Organizer Proteins in Health and Disease, Genetics to understand cellular components of Alzheimer Disease pathogenesis, Exploiting the pathophysiology of the gut towards innovative oral peptide delivery strategies, Transcription-replication conflicts in disease and development, Unravelling the heterogeneity and functions of hepatic myeloid cells in Non-Alcoholic Fatty Liver Disease, Ex vivo cell labelling for in vivo imaging applied to cell therapeutics, KerecisTM Omega3 Wound: the first fish skin substitute in the European Market for chronic wound care, affecTive basEd iNtegrateD carE for betteR Quality of Life, Vegetable Ozone Therapy Crops Sanitized Naturally from Seed to Feed, Intelligence for precision therapies against antimicrobial resistance: The first diagnostic panel that probes all the clinically relevant antibiotics at once, Commercialising cardiac autonomic modulation to treat Atrial Fibrillation, Insoles for Neuropathy and Balance Issues, The European first generation of aquaculture SERS-based Biosensor, A medical device for the selective dissection of pathological tissues and fibrosis, Oralis, The first oral human insulin treatment for Type 2 Diabetes Mellitus, Molecular physiology of nerve terminal bioenergetics, PHAGOSCOPY: Dissecting cell-autonomous immunity with ex vivo electron cryo-microscopy, Integrated silicon photonics for Cardiovascular Disease monitoring, INTEGRATED PERSONALIZED CARE FOR PATIENTS WITH ADVANCED CHRONIC DISEASES TO IMPROVE HEALTH AND QUALITY OF LIFE, Patients-centered SurvivorShIp care plan after Cancer treatments based on Big Data and Artificial Intelligence technologies, Obsidian Anastomotic SafeGuard – A powerful and efficient tissue sealant method for reducing the anastomotic leak rate in colorectal surgery, Shaping of long term innate immunity by viral education of bone marrow monocytes, Artificial intelligence Supporting CAncer Patients across Europe, a Federated Artificial Intelligence solution for moniToring mental Health status after cancer treatment, Disruptive Real World Data & Real World Evidence Internet of Things platform for faster and more accurate clinical studies, Post-transcriptional regulation of RNA degradation in early zebrafish development, High throughput multiplexed trace-analyte screening for diagnostics applications, Discovering novel antibodies derived from the human body itself to treat neurodegenerative diseases, Point of Care Diagnostic Test for the Differential Diagnosis of Inflammatory Bowel Disease, THE ORGANIC FERTILISER FOR GENUINE, HIGH YIELD PESTICIDE AND CHEMICAL-FREE ORGANIC FARMING, A diagnostic device for personalized determination of vitamin B6 status and health, Dissecting the chromatin response to DNA damage in silenced heterochromatin regions, Early recognition of intracranial aneurysms to PRevent aneurYSMal subarachnoid hemorrhage, Exploring Visual Processes with Two-Photon Ophthalmoscopy, NORATEST: An e-Health solution for a better Alzheimer's diagnosis and management, Targeting the brain sigma-1 receptor: A paradigm shift for the treatment of neuro-degenerative disorders, AI-based infectious diseases diagnosis in seconds, Predicting comorbid cardiovascular disease in individuals with mental disorder by decoding disease mechanisms, Retinal and cognitive dysfunction in type 2 diabetes: unraveling the common pathways and identification of patients at risk of dementia, Comorbid Analysis of Neurodevelopmental Disorders and Epilepsy, Molecular Mechanisms Associating Chronic Pain with Fatigue, Affective Disorders, Cardiovascular Disease and Total Comorbidity, Analysis of eye vergence responses for the early detection and monitoring of cognitive and mental disorders, Gene Therapy to restore lymphatic flow lymphedema, HCA|Organoid: Pilot action to establish a multi-tissue human organoid platform within the Human Cell Atlas as a booster of future disease-centric, mechanistic, and translational research, Multivalent interactions driving RNP dynamics in development and disease, Halogen metabolism of brown macroalgae and its biological significance in the context of pathologies - An omics approach, Deciphering the cellular origin and evolution of malignant rhabdoid tumors, Bacteria-mucin interactions – Shaping intestinal epithelial responses in health and disease, Promyelocytic leukemia protein (PML) outside the tumor: a new player in the control of inflammation, EU Patient- cEntric clinicAl tRial pLatform, A training network for the design of new synthetic carbohydrate-based vaccines to combat antibiotic resistant Pseudomonas aeruginosa, Shaping the Mechano-Pharmacological properties of Microparticles and Extracellular Vesicles for the Treatment of Osteoarthritis, Integrative structural biology of pathological tau protein, an appealing therapeutic target for Alzheimer´s disease modifying drugs, Sparing gene therapy for Inherited ROd COne dystrophies, Implementation and preclinical testing of a closed-loop control system for deep brain stimulation, Automated Cellular Robot-Assisted Technologies for translation of discovery-led research in Osteoarthritis. Mucosal Tolerance and Allergic Predisposition: Does it all start in the gut? Impact of vector-mediated transmission on the evolution and ecology of a bee virus, Individual differences in facial expressivity: Social function, facial anatomy and evolutionary origins, Mechanisms of Microglia Synapse Communication, Targeting leukaemia by modulating hematopoietic stem cell competitiveness, The molecular basis and genetic control of local gene co-expression and its impact in human disease, Engineered nanocarriers for simultaneous anticancer immune response and “switching” of tumor-associated macrophages for intranasal glioblastoma treatment, Cross-linking Adenosine Receptors - Estrogen receptors for OA treatment, Unraveling the Molecular Changes that Drive the Repression of the Unfolded Protein Response with Ageing. A National Plan that primarily targets HABs and their toxins in marine and estuarine waters has been developed, Harmful Algal Research and Response: A National Environmental Science Strategy 2005-2015, (HARNESS 2005), but an analogous plan for freshwater HABs has not been developed. : 116106, Rheumatoid Arthritis Caught Early: investigating biological mechanisms preceding chronification of joint inflammation to identify patients prior to presentation of classic chronic arthritis, Tracking and predicting neurodegeneration spreading across the brain connectome, How to build a brain? Immuno-targeting of human AML quiescent cells by a novel phage display approach. A Non-Invasive GLUCOse MONitoring device for diabetics based on Stimulated Raman Spectroscopy in a quick, cheap and painless method. Transcript. Discovering the cellular landscape of the airways and the lung, EXposome Powered tools for healthy living in urbAN SEttings, Molecular atlas of the brain across the human lifespan, Dynamic longitudinal exposome trajectories in cardiovascular and metabolic non-communicable diseases, Impact of exposome on the course of lung diseases, Versatile Emerging infectious disease Observatory, Mapping Exposure-Induced Immune Effects: Connecting the Exposome and the Immunome, New Generation Cell Therapy: Bioartificial Pancreas to Cure Type 1 Diabetes, Computational biomechanics and bioengineering 3D printing to develop a personalized regenerative biological ventricular assist device to provide lasting functional support to damaged hearts, Human Exposomic Determinants of Immune Mediated Diseases, MOnitoring Outbreak events for Disease surveillance in a data science context, Dipeptide-Repeat Vaccine to prevent ALS and FTD in C9orf72 mutation carriers, ENDObronchial microWAVE Ablation for the minimally invasive treatment of lung cancer, Wearable Sweat-based painless and continuous glucose monitoring device for diabetic people, Development, dIagnostic and prevention of gender-related Somatic and mental COmorbitiEs in iRritable bowel syndrome In Europe, Drug combinations for rewriting trajectories of renal pathologies in type II diabetes (DC-ren), EUROPEAN REGIMEN ACCELERATOR FOR TUBERCULOSIS, Understanding how mitochondria compete with Toxoplasma for nutrients to defend the host cell. Dynamic Complexes and Allosteric Regulation of Small Molecule Transporters, An effective and safe targeted therapy for treatment of Myasthenia gravis, Navigating lymphatic formation and function in health and disease, Deciphering and predicting the evolution of cancer cell populations, Hepatocytes-Like Microreactors for Liver Tissue Engineering, Clinical assessment of PILA PHARMA’s TRPV1 antagonist, XEN-D0501, as a novel type of oral anti-diabetic agent, Ser-Col; from finger to laboratory; personalized and automated serum collection for laboratory diagnostics, Disease Risk And Immune Strategies In Social Insects, Enteric-nervous-system-mediated regulation of intestinal inflammation, Development of lipid nanoparticles based on solid matrix for Benznidazole oral delivery targeting to the lymphatic system to treat Chagas disease, The core and effects of epilepsy: from chronic disease to curable disorder through innovative guided surgery, Bioengineering lung tissue using extracellular matrix based 3D bioprinting, Advancing osteoporosis medicine by observing bone microstructure and remodelling using a four-dimensional nanoscope, Innovative Network for Next Generation Training and Sequencing of Virome, Apoptotic foci: composition, structure and dynamics, Exploring the Epigenome by Multiplexed Physical Mapping of Individual Chromosomes, spontaneous Evolution and Clonal heterOgeneity in MoNoclonal Gammopathies: from mechanisms of progression to clinical management, Targeting the epigenome: towards a better understanding of disease pathogenesis and novel therapeutic strategies in Multiple Sclerosis, Therapeutic Allele Engineering: A novel technology for cell therapy, Identifying spatial determinants of immune cell fate commitment, Regulation of Brain Macrophage Development and Function, Infinite Protein Self-Assembly in Health and Disease, Decoding interactions between adipose tissue immune cells, metabolic function, and the intestinal microbiome in obesity, Brain cell type-specific interactions and schizophrenia, A unified drug discovery platform for protein misfolding diseases, PanCareFollowUp: Novel, patient-centred survivorship care to improve care quality, effectiveness, cost-effectiveness and accessibility for survivors and caregivers, REACH: Russian European Alliance for research among women, Children and adolescents impacted by HIV, TB and HCV, Project on Exercise for Fatigue Eradication in Advanced Breast cancer to improve quality of life, Living well, dying well. Targeting epigenetic demethylases: development of covalent inhibitors and PROTACs (Proteolysis Targeting Chimeras). An Embolic Protection Device for stroke prevention during heart valve replacement. Constructing an evolutionary atlas of the immune landscape in lung cancer. Functional characterisation of mitochondrial metabolic adaptations to innate sensing in dendritic cell subsets, Elimination of Senescent Cells Approach for treatment of COPD, Molecular mechanisms of endosome departure from the spindle in asymmetric cell division, Balancing the immune response in cystic fibrosis: using zebrafish models of infection and inflammation to uncover new therapeutic approaches, Direct reprogramming for HD Disease Modelling, Advanced platform for profiling of therapeutic targets and functional analysis of circulating tumour cells in cancer patients, Nichoid: nanoengineered three-dimensional substrate for stem cell expansion, Therapeutic antibody drug monitoring using bioluminescent sensors proteins and a smartphone, Beehive health IoT application to fight Honey Bee Colony Mortality, Collective Infectious Units and the Social Evolution of Viruses, Nanoengineering of radioactive seeds for cancer therapy and diagnosis, Single-cell temporal tracking of epigenetic DNA marks, Whispering the language of the neurons to restore vision, Modelling Neuron-Glia Networks into a drug discovery platform for Pain Efficacious Treatments - Sofia ref. Single-Cell Transcriptomics and Spliceosome analysis to uncover new mechanisms of neuronal vulnerability to Huntington’s Disease. Breaking and rebuilding the genome: mechanistic rules for the dangerous game of sex. The polyphosphate/factor-XII pathway in cancer-driven thrombosis and tumor growth, MicroRNA Isoforms for Molecular Interception of Cervical cancer using Self-samples, Assistive Devices for the Visually Impaired and other Disabilities, Discovery and commercialisation of novel compounds targeting redox proteins, Neogenesis of new functional Beta Cells through Modulation of Neurogenin-3 Expression to provide Regenerative Therapy for Diabetes Patients, Hybrid Volumetric Optoacoustic-Ultrasound Tomography for Noninvasive Large-Scale Recording of Brain Activity with High Spatiotemporal Resolution, polyValent mEsopoRous nanosystem for bone DIseases, Brain network based stratification of mental illness, Composition and Mechanism of the DNA-uptake Pilus of Vibrio cholerae, Mechanisms of cellular fatty acid homeostasis, Bendable Bioplatform for Electrically stimulated Neuronal Differentiation. How does the ubiquitin-like protein NEDD8 activate ubiquitin ligase machineries? Identification and characterization of enteric nervous system stem cells, Study of the role of BANK1 in antibody production and antibody-independent functions of B cells in SLE, Revolutionizing Healthcare by Tracking and Understanding Human Cells during Disease, Targeting drug resistance in ovarian cancer through large-scale drug-response profiling in physiologically relevant cancer organoids, Evolutionary history of the sickle cell trait among Central African hunter-gatherers and farmers, Impact of maternal Adrenomedullin on the Microbiome and Gut health: insights into preventing chronic intestinal disorders, Molecular Details of Membrane Protein Receptor Dynamics. CaMKII over stimulation in engineered heart tissues (EHTs) made from human induced pluripotent stem cells (hiPSCs): a parameter involved in the immaturity of hiPSC EHTs cardiomyocytes? Admixture accelerated adaptation: signals from modern, ancient and archaic DNA. The new and most efficient multiple biomarkers-based system for an early selection of RA treatment intensity. In conjunction with large-scale deployment of carbon storage as a technology, there is an urgent need for tools which provide reliable and quick assessments of aquifer storage performance. A Clinical Phase IIB trial with 2OHOA in patients with newly-diagnosed malignant glioma. Use of novel techniques to identify pathogenic versus non-pathogenic TH17 cells in experimental autoimmune encephalomyelitis, a murine model of multiple sclerosis. Engineering molecular systems for mechanosensation and -protection in neurons, Single Molecule Nanoscale Sensors for Improved Therapies and Diagnostics, Understanding the complexity and architecture in protein ubiquitination, Maternal Enteric Microbiota for Offspring's Repertoire development and Illness Susceptibility, An Integrated Computational and Experimental Approach to Rapid Synthesis of Highly Selective Dual-Targeted HDAC/CK2, MMP2/CK2 Inhibitors. Harris, John. A Translational Approach, Data science tool for Epidemic FOrecastinG, A nanovaccine Approach for the treatment of Pancreatic Cancer, Diagnostic drug response-profiling using SLAMseq, Small-Molecule Drug Conjugates for Targeted Delivery in Tumor Therapy. DualDur: A Disruptive Diagnostic Technology that Enables for the First Time an Early and Accurate Diagnosis of the tick-borne Lyme Disease. Development of a platform for a new model of interaction between geneticists and patients with Mendelian diseases. Self-amplified photonic biosensing platform for microRNA-based early diagnosis of diseases, PERvasive Serious GAMes suppOrted by Virtual CoachiNg, Plasmonic-based autOmated lab-on-chip SEnsor for the rapid In-situ Detection of LegiONella, Multimedia Authoring and Management using your Eyes and Mind. PROMOTING ACTIVE AGEING: FUNCTIONAL NANOSTRUCTURES FOR ALZHEIMER’S DISEASE AT ULTRA-EARLY STAGES. Accurate and Non-Invasive Medical Device for the Diagnosis of Early Stage Alzheimer's Disease. Sex in malaria parasites – from basic biology to targets for transmission blocking interventions. : 116060, Single cell genomic analysis and perturbations of hematopoietic progenitors: Towards a refined model of hematopoiesis. Non-histone protein acetylation targets of KAT2A in AML, Human Lung Microbiota And Innate Immunity. It is a cluster of metabolic diseases characterized by high blood sugar levels. Mechanisms that maintain centromere DNA repeats stability in human cells. iRhom2 in neuroinflammation and pathogenesis of Alzheimer’s Disease, Analysis of tridimensional changes caused by type 2 Diabetes-Associated varianTs, Genetic analysis of rare and common variation in a large Brazilian bipolar family, Planning and Evaluation Methodologies for Mental Healthcare Buildings, Real-time up-conversion luminescence thermometry based on lanthanide doped nanodiamonds in a living cell. Bioinformatics platform for profiling of health: allowing early and accurate detection of multiple diseases simultaneously, Toilet IoT sensor for medical monitoring and wellness tool, Development of an innovative Airway-on-Chip microbiome cell culture model to investigate host-microbiome interactions at the airway epithelial surface, How dopamine affects social and motor ability - from the human brain to the honey bee, What is Tuberculosis? A novel in vivo platform to study and target undruggable Ewing onco-chimera. Discovery and characterization of food bioactive compounds modulating the Pentose Phosphate Pathway against non-alcoholic fatty liver disease. GlioDx - Blood platelet-based monitoring and treatment optimisation for glioblastoma patients, Translating fundamental insights in endothelial metabolism: PFKFB3 drug discovery and development, A novel immunity-based test for early diagnosis of Lyme disease, Cell therapy for patients with chronic heart failure with proprietary cardiac-derived cells (CardAP cells) – “From the Heart to the Heart”, Zebrafish avatar as a real-time in vivo platform for personalized cancer therapeutics, MAGTEST: Simple and specific next generation lab-on-a-chip in-vitro molecular diagnostic device, Arthroscopic Regenerative Medicine for Early-Stage Treatment of OA, A novel class of antibiotics for treatment of infected atopic dermatitis: an innovative solution for a significant unmet medical need, Integrated next-generation flow cytometry and sequencing to uncover the pathway of curability in multiple myeloma, Reversing the epigenetic state of oligodendrocyte precursors cells in multiple sclerosis, Development of a potent dual GCS/GBA2 inhibitor as a best in class Gaucher therapeutic, Memory and innate-like B-cell subsets: deciphering a multi-layered B-cell response in mice and humans, Cellular diversity and stress-induced cell-state switches in the mammalian hypothalamus, Fast tracking market adoption of a novel immune-based diagnostic for improving antibiotic stewardship: automation, piloting and health economics, Functional interactions between endoplasmic reticulum and mitochondria in Drosophila axons, INdividual Vascular SignaTure: A new machine learning tool to aid personalised management of risk for cardiovascular disease. 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