If the offending agent can be identified and removed, patients often improve. With early diagnosis and prevention, the prognosis is good. Policy. However, this may take several years for subacute forms. People working in certain occupations are more likely to develop HP. Last reviewed by a Cleveland Clinic medical … It represents a collaborative effort among the American Thoracic Society, Japanese Respiratory Society, and Asociación Latinoamericana del Tórax. What is the prognosis (outlook) for people with hypersensitivity pneumonitis? We do not endorse non-Cleveland Clinic products or services. Symptoms of Pulmonary Fibrosis. Diagnosis … Hypersensitivity Pneumonitis. Hypersensitivity pneumonitis (HP), also known as extrinsic allergic alveolitis (EAA), represents a group of pulmonary disorders mediated by an inflammatory reaction to inhalation of an allergen that can lead to lung fibrosis. Hypersensitivity pneumonitis represents a major diagnostic conundrum. Living with the condition will likely require significant support . These may be organic or inorganic particles (microbes, animal or plant proteins, and certain chemicals) that form haptens by sensitised individuals. Acute, subacute, and chronic forms exist; all are characterized by acute interstitial inflammation and development of granulomas and fibrosis with long-term exposure. This kind of hypersensitivity pneumonitis can lead to permanent lung scarring. Hypersensitivity pneumonitis is a rare disease that can cause a build-up of scarring in the lungs. Managing Hypersensitivity Pneumonitis For people living with chronic hypersensitivity pneumonitis, it is very important to take care of your overall health. In most cases, disease can be reversed with prompt … In th… 134(1):133-8. Hypersensitivity pneumonitis is typically divided into two types based on how long you have been affected and how severe your symptoms are. Methods: Systematic reviews were performed for six q … American Lung Association. Pneumonitis, however, is usually used by doctors to refer to noninfectious causes of lung inflammation.Common causes of pneumonitis include airborne irritants at your job or from your hobbies. Chest Foundation. Merck Manual Professional Version. It represents a collaborative effort among the American Thoracic Society, Japanese Respiratory Society, and Asociación Latinoamericana del Tórax. [clarification needed] A multinucleated giant cell, seen within the interstitium to … Normally, people who work in areas where there is abundant amount of dust that may contain fungus, molds etc. In some cases lung transplantation is required. Managing hypersensitivity pneumonitis requires a combination of medications and behavioral changes. A face-to-face discussion among these various specialists is often necessary to make an accurate diagnosis. This condition is caused over a prolonged period of exposure to the allergen, which may span several years. A multidisciplinary committee of international experts have released a new clinical practice guideline on the diagnosis of adult hypersensitivity pneumonitis (HP), an immune-mediated inflammatory lung and small airway disease. Crossref, Medline, Google Scholar; 77 Lima MS, Coletta EN, Ferreira RG et al.. Subacute and chronic hypersensitivity pneumonitis: histopathological patterns and survival. Desquamative interstitial pneumonitis- most common among smokers and those with a history of smoking. Hypersensitivity pneumonitis. Many people with acute HP recover by avoiding allergens. Allergens are substances that cause an allergic reaction in the body. HP results from breathing in specific environmental allergens. Pneumonitis is treatable. Although the symptomatic disease has been classically divided into acute, subacute, and chronic types, given contradictory definitions, it has been more recently divided in acute/inflammatory type (non-fibrotic hypersensitivity pneumonitis) and chronic/fibrosis type (fibrotic hypersensitivity pneumonitis) 3,13. Hypersensitivity pneumonitis (HP) is a lung disease causing inflammation (swelling and sensitivity) of the lung tissue. Hypersensitivity pneumonitis (HP) happens if your lungs develop an immune response – hypersensitivity - to something you breathe in which results in inflammation of the lung tissue - pneumonitis. Workers in certain jobs have increased exposure to allergens and an increased risk of this condition. Certain findings can be very suggestive such as air trapping, centrilobular nodules (tiny little nodules in the lungs) and the upper part of the lungs being more involved than the lower part of the lungs. Hypersensitivity pneumonitis (HP) is an immune-mediated syndrome triggered by inhalation of a wide variety of allergens, to which an individual has previously been sensitized. This condition is called pulmonary fibrosis. 9500 Euclid Avenue, Cleveland, Ohio 44195 |. In general, most cases of IPF can be distinguished from hypersensitivity pneumonitis though atypical presentations of IPF may have some overlapping characteristics. Often we are not able to identify the specific cause of the lung process. Cleveland Clinic is a non-profit academic medical center. Chronic hypersensitivity pneumonitis (CHP) refers to hypersensitivity pneumonitis where there is radiological evidence of fibrosis and represents the end-stage of repeated or persistent pneumonitis 7. There are slight variations in both the time of onset and the severity of symptoms experienced in the three forms of hypersensitivity pneumonitis.. Aim. In patients with acute HP, avoidance will result in a good prognosis. This step should help lessen your symptoms. Hypersensitivity pneumonitis (HP) is a lung disease causing inflammation (swelling and sensitivity) of the lung tissue. Hypersensitivity pneumonitis (HP) is caused by inhalation of environmental antigens. Hypersensitivity pneumonitis; Other names: Allergic alveolitis, bagpipe lung, extrinsic allergic alveolitis (EAA) High magnification photomicrograph of a lung biopsy taken showing chronic hypersensitivity pneumonitis (), showing mild expansion of the alveolar septa (interstitium) by lymphocytes. Background: This guideline addresses the diagnosis of hypersensitivity pneumonitis (HP). Pneumonitis is also called hypersensitivity pneumonitis. Hypersensitivity pneumonitis (HP), also known as extrinsic allergic alveolitis, is an immune-mediated syndrome that results from lung parenchyma and small-caliber respiratory tract inflammation. Accessed 8/13/2018. Hypersensitivity pneumonitis (HP), or extrinsic allergic alveolitis, is an inflammatory syndrome of the lung caused by repetitive inhalation of antigenic agents in a susceptible host. 1. In a study involving Korean patients with chronic hypersensitivity pneumonitis, showed old age, low levels of bronchoalveolar lavage fluid lymphocyte, and poor lung function mean poor prognosis 10). One example is farmer’s lung. Certain medications may also cause this reaction. Context: - Chronic hypersensitivity pneumonitis (CHP) has emerged from obscurity during the past 15 years and is now recognized as a very common form of fibrosing interstitial pneumonia but one that is frequently misdiagnosed both clinically and on surgical lung biopsy as usual interstitial pneumonia/idiopathic pulmonary fibrosis (UIP/IPF) or fibrotic nonspecific interstitial pneumonia. Therefore, there is an urgent need to identify factors which predict prognosis and survival in patients with HP. High-resolution CT findings of parenchymal fibrosis correlate with prognosis in hypersensitivity pneumonitis. Long-term exposure can lead to lung inflammation and acute lung disease.Over time, the acute condition turns into long-lasting (chronic) lung disease. Background: This guideline addresses the diagnosis of hypersensitivity pneumonitis (HP). CORONAVIRUS: DELAYS FOR ROUTINE SURGERIES, VISITOR RESTRICTIONS + COVID-19 TESTING. Sarcoidosis- inflammation affects organs of the body. Acute interstitial pneumonitis- chronic but sudden type of ILD. Chronic hypersensitivity pneumonitis develops after numerous or continuous exposures to small amounts of the allergen. Subacute: This form of hypersensitivity pneumonitis develops more gradually or … Last reviewed by a Cleveland Clinic medical professional on 08/09/2018. In acute and subacute forms, most patients recover lung function completely when exposure to the antigen stops. Symptoms of Hypersensitivity Pneumonitis. Hypersensitivity Pneumonitis. Other times the disease progresses despite moving homes and our best efforts. The present report provides an … This step should help lessen your symptoms. Previous: Prevention Next: Living With. Chronic hypersensitivity pneumonitis (CHP) has a variable disease course. The symptoms of chronic HP develop over months or years. Over time, the acute condition turns into long-lasting (chronic) lung disease. The disease is slowly progressive for the most part, though there is a form that is more dramatic with fevers and rapidly progressive symptoms. Chest. Find more signs and symptoms information here. If you have hypersensitivity or chemical pneumonitis, your doctor will recommend eliminating exposure to the allergen or chemical irritating your lungs. It can lead to irreversible lung scarring over time. Many people with episodes of hypersensitivity pneumonitis are probably unrecognized and undiagnosed. These allergens may be present at home, at work, or in nature. Explore lung, breathing and allergy disorders, treatments, tests and prevention services provided by the Cleveland Clinic Respiratory Institute. Policy, Cleveland Clinic is a non-profit academic medical center. Hypersensitivity Pneumonitis as stated is caused by inhalation of particulates to which the body is allergic to. If there is significant fibrosis, it is unlikely that pulmonary function tests will normalise. Hypersensitivity pneumonitis usually occurs in people who work in places where there are high levels of organic dusts, fungus, or molds. Chronic hypersensitivity pneumonitis (cHP) is an immunologically mediated lung disease caused by a persistent or repeated exposure to inhaled environmental or occupational antigens resulting in bronchoalveolar inflammation and progressive fibrosis … One of the non-IPF causes of pulmonary fibrosis is chronic hypersensitivity pneumonitis. This inflammation makes breathing difficult. Advertising on our site helps support our mission. Diagnosis of hypersensitivity pneumonitis requires a high index of suspicion in patients with compatible symptoms and a compatible occupational, avocational, or domestic exposure history. Hypersensitivity pneumonitis (HP) is an interstitial lung disease with a better prognosis, on average, than idiopathic pulmonary fibrosis (IPF). Some cases believed to be viral pneumonias may actually be hypersensitivity pneumonitis. Hypersensitivity pneumonitis- caused by exposure to different type of irritants, dust or molds. Accessed 8/13/2018. Chest x-ray, HRCT, and pulmonary function tests are done routinely. Hypersensitivity pneumonitis (HP) is an immunologically mediated lung disease resulting from exposure to inhaled environmental antigens. Hypersensitivity pneumonitis (HP), also known as extrinsic allergic alveolitis, represents a group of pulmonary disorders mediated by an inflammatory reaction to inhalation of an allergen. Share Facebook Twitter LinkedIn Email Print. Pulmonary function tests often show a mixed picture of abnormalities. The median follow-up period was 24.8 months and the mean age of patients was 60.4 years, 60.4% were female and 33.7 % died during follow-up. Clinical manifestations of hypersensitivity pneumonitis may closely mimic other interstitial lung diseases, and the disease onset is usually insidious. Most cases of hypersensitivity pneumonitis develop only after many years of continuous or intermittent inhalation of the inciting agent (e.g. For patients with clinical and Hypersensitivity pneumonitis symptoms. 29) between seven multidisciplinary teams from different countries on the diagnosis of hypersensitivity pneumonitis vividly reveals the magnitude of the … Hypersensitivity pneumonitis (HP) is categorized as acute, subacute, and chronic based on … Hypersensitivity Pneumonitis. Hypersensitivity pneumonitis is a long-term condition that will require ongoing treatment to manage the symptoms. Patients complain of shortness of breath and cough. Acute: This form of hypersensitivity pneumonitis develops in four to six hours after heavy exposure to an allergen. Computer analysis of CT features was used to identify a subset of CHP patients with an outcome similar to patients with idiopathic pulmonary fibrosis (IPF). Some people develop chronic hypersensitivity pneumonitis. In certain settings the imaging may be diagnostic. Copyright © 2021 Inspire Pulmonary Media, LLC | Disclaimer| Google +, Symptoms of Idiopathic Pulmonary Fibrosis, Gastro-Esophageal Reflux (GER) and Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease vs. Idiopathic Pulmonary Fibrosis, Research, Life Expectancy and Prognosis for Idiopathic Pulmonary Fibrosis, Complications of Idiopathic Pulmonary Fibrosis, Lung Transplantation for Pulmonary Fibrosis, Clinical Trials in Idiopathic Pulmonary Fibrosis, Pulmonary Hypertension and Idiopathic Pulmonary Fibrosis, Leg swelling, lung biopsy, side effects & pets, FAQ’s Enzyme Therapy, Progression of IPF & Oxygen, FAQ: Diarrhea, Fibrosis Reversal, IPF Symptoms, FAQ: Contagious Cough? ~ 10 years among those with bird fancier’s lung) 3. Long-term exposure can lead to lung inflammation and acute lung disease. Hypersensitivity pneumonitis (HP) is an immunologically mediated lung disease resulting from exposure to inhaled environmental antigens. But this allergic reaction is not sneezing and nasal congestion but inflammation in your lungs. This reaction is secondary to repeated and prolonged specific antigens inhalation to which an individual is sensitized. This leads to a chest xray... Prognosis. More than 200 agents responsible for the disease have already been identified; however, HP occurs only in a small number of individuals exposed to causal antigens. Most patients … We do not endorse non-Cleveland Clinic products or services. Hypersensitivity pneumonitis is subdivided into two forms: acute and chronic. If diagnosed, some types of hypersensitivity pneumonitis are treatable by avoiding exposure to the environmental substances or with medicines such as corticosteroids that reduce inflammation. PULMONARY PERSPECTIVE Hypersensitivity Pneumonitis: Perspectives in Diagnosis and Management Martina Vasakova1, Ferran Morell2, Simon Walsh3, Kevin Leslie4, and Ganesh Raghu5 1Department of Respiratory Medicine, First Faculty of Medicine of Charles University, Thomayer Hospital Prague, Prague, Czech Republic; 2Vall d’Hebron Institut de Recerca, Servei … The allergens contain fungus spores (small parts of the fungus) from moldy hay or bird droppings. You may feel as if you have caught the flu when an acute attack … The symptoms usually clear up in a day or two if there is no more exposure to the reaction-causing material. The chronic form of the disease may not respond fully despite aggressive use of these medications. These cases usually are treated successfully. High-resolution computed tomography and bronchoalveolar lavage are the sensitive and characteristic diagnostic tests for hypersensitivity pneumonitis. Symptoms of acute HP may include: In rare cases, chronic HP leads to irreversible, permanent scarring of the lung tissue. National Heart, Lung, and Blood Institute. This includes staying up-to-date with your vaccinations, eating a healthy diet and exercising regularly. ... Outlook (Prognosis) Most symptoms go away when you avoid or limit your exposure to the material that caused the problem. The aim of the present report is to increase awareness of the association between methotrexate and the possible risk of … The syndrome varies in intensity, clinical presentation, and natural history depending on … Diagnosis Diagnosing hypersensitivity pneumonitis can be difficult and requires input from pulmonologists, radiologists and, in many cases, pathologists experienced in evaluating patients with interstitial lung disease. The HP diagnosis is based on clinical symptoms (cough, dyspnea) in a person exposed to environmental antigens, and the presence of characteristi … [Hypersensitivity pneumonitis: Diagnostic criteria, treatment, prognosis … Methods: Systematic reviews were performed for six questions. INTRODUCTION. Hypersensitivity pneumonitis (HP) must be considered in the differential diagnosis for patients with newly identified interstitial lung disease (ILD). The symptoms of HP depend on whether the disease is acute or chronic. In one form of hypersensitivity pneumonitis, a cough and shortness of breath may take days or weeks to develop and be so severe that the person needs to be hospitalized. Accessed 8/13/2018. Hypersensitivity pneumonitis: the first diagnostic guidelines The field of interstitial lung diseases (ILDs) is one of the most challenging in terms of diagnosis and management. Prognosis is variable, with a subset of patients developing progressive fibrosis leading to respiratory failure and death. Usually the lymph nodes and the lungs. The most important treatment of hypersensitivity pneumonitis is avoidance of repeated exposures to the offending particles. Treatment The most important thing you can do is avoid the dust that caused your hypersensitivity pneumonitis. Repeated exposure to allergens can cause hypersensitivity pneumonitis, or inflamed lung tissue. You may get symptoms like shortness of breath, tiredness, coughing, and weight loss that slowly get worse. It results in a type III hypersensitivity inflammatory response and can progress to become a chronic condition which is considered potentially dangerous. These include: HP results from inhaling certain allergens into the lungs. 1 More than 200 antigens have already been identified as … Diagnosis … Patients with more advanced disease may require oxygen and even develop pulmonary hypertension as a result of progressive scarring of the lungs. Prognosis is variable, with a subset of patients developing progressive fibrosis leading to respiratory failure and death. Some classic examples are allergic reactions to mold in the walls and bird feathers in patients who have birds inside the house. If you are a smoker, quitting smoking will slow the worsening of your disease. The guideline committee categorized HP into two clinical phenotypes— nonfibrotic and fibrotic HP—and made separate recommendations for each: a. Hypersensitivity pneumonitis occurs in people when the body’s immune system overreacts and develops an overly exuberant immune reaction to foreign substances, known as antigens, that they have breathed in. It can lead to irreversible lung scarring over time. This inflammation makes it harder for the lungs to function properly and may even permanently damage the lungs. Early recognition and control of exposure are key to outcome. Complete recovery, however, may take weeks. In hypersensitivity pneumonitis (HP) - now the preferred term for extrinsic allergic alveolitis ... Prognosis. In general, acute (or sudden) HP symptoms occur 4- 6 hours after allergens are inhaled. “hypersensitivity pneumonitis”, “extrinsic alveolitis”, “farmers lung” and synonyms, “pigeon/bird fanciers’ lung” and synonyms and “prognosis”, “disease course”, “outcomes” and “survival”. Bronchoalveolar lavage and lung biopsy may be necessary if results are inconclusive. Hypersensitivity pneumonitis is caused by something in the environment (usually your home or work) to which you develop an allergic reaction. Its diagnosis relies on a constellation of findings: exposure to an offending antigen, characteristic signs and symptoms, abnormal chest findings on physical … To distinguish pneumonitis from other lung disorders, you'll likely have one or more of the following tests. In patients with sub-acute or chronic HP, the prognosis depends not only on the ability to avoid the causative antigen but also on the lung function at diagnosis, and the amount of fibrosis that has already occurred. Bird feathers and droppings, and household mold are examples of common allergens. If you are a smoker, quitting smoking will slow the worsening of your disease. Churg A(1), Sin DD, Everett D, Brown K, Cool C. Author information: (1)Department of Pathology, University of British Columbia, Vancouver, BC, Canada. It used to be called extrinsic allergic alveolitis (EAA). The syndrome varies in intensity, clinical presentation, and natural history depending on the inciting agent, as well as the intensity of exposure. This serious disease causes symptoms resulting from too little oxygen reaching body tissues. Managing Hypersensitivity Pneumonitis. Prolonged, repeated exposures can lead to permanent lung damage, scarring, and … Hypersensitivity pneumonitis is a syndrome of cough, dyspnea, and fatigue caused by sensitization and subsequent hypersensitivity to environmental (frequently occupational) antigens. These allergens may be present at home, at work, or in the air. Respir Med 2009;103(4):508–513. Symptoms differ for each form. Patients have symptoms of cough and shortness of breath. Acute, subacute, and chronic forms exist; all are characterized by acute interstitial inflammation and development of granulomas and fibrosis with long-term exposure. This leads to a chest xray and eventually a high resolution CT scan of the lungs. Because they occur naturally, they are called organic. Bronchoalveolar lavage and lung biopsy may be necessary if results are inconclusive. This inflammation makes breathing difficult. The relevant antigen to hypersensitivity pneumonitis cannot be identified in up to … Granuloma … Nevertheless, it can be assumed that all patients starting MTX are at risk of MTX‐P. The patient's history of repeated episodes of typical symptoms, hours after exposure to certain environments are important in establishing the diagnosis. When it reaches the chronic stage, … Bird fancier's lung has a worse prognosis … Chest x-ray, HRCT, and pulmonary function tests are done routinely. 2008 Jul. Advertising on our site helps support our mission. Farmer's lung (not to be confused with silo-filler's disease) is a hypersensitivity pneumonitis induced by the inhalation of biologic dusts coming from hay dust or mold spores or any other agricultural products. Therefore, there is an urgent need to identify factors which predict prognosis and survival in patients with HP. Diagnosis of hypersensitivity pneumonitis requires a high index of suspicion in patients with compatible symptoms and a compatible occupational, avocational, or domestic exposure history. In many cases, the lungs remain inflamed over time, with repeated exposure to an allergen. Pathologic patterns and survival in chronic hypersensitivity pneumonitis. Hypersensitivity pneumonitis usually occurs in people who work in places where there are high levels of organic dusts, fungus, or molds. Pneumonitis (noo-moe-NIE-tis) is a general term that refers to inflammation of lung tissue. In turn, this could lead to scarring. Over 300 substances are known to cause HP, including: These substances cause inflammation of the lung tissue when inhaled. Farmers, including those working with dairy cattle or vegetables, Animal handlers, including veterinarians and bird or poultry handlers, People who process and load grains or flour, Individuals working in lumber mills or who strip wood, Certain individuals in the electronics, plastic manufacturing, and painting industries, Keeping pet birds and breathing allergens from bird droppings or feathers (known as bird fancier’s lung), Breathing allergens from humidifiers, heating systems, or air conditioners, especially if they are not cleaned properly or well-maintained (humidifier lung), Inhaling bacteria found in hot tub water vapor (hot tub lung), Shortness of breath, especially with exertion or activity, Finger and toe clubbing (rounding and widening). More than 200 different antigens have been … Chronic Hypersensitivity Pneumonitis Causes of Hypersensitivity Pneumonitis. An abbreviated overview of the guideline summary has been published in the Annals of the American Thoracic Society. Patients complain of shortness of breath and cough. In addition, some types of cancer treatments and dozens … You are more likely to develop chronic hypersensitivity pneumonitis if you are exposed to low levels of allergens constantly over an extended period. Hypersensitivity pneumonitis is a syndrome of cough, dyspnea, and fatigue caused by sensitization and subsequent hypersensitivity to environmental (frequently occupational) antigens. Symptoms may include shortness of breath, tiredness, coughing that lasts weeks or months and weight loss that gets progressively worse. Medications such as prednisone and other immunosuppressants are often used with benefit. HP results from breathing in specific environmental allergens. Many cases of HP occur acutely (suddenly). This disease is probably more common than we think. Technically, pneumonia is a type of pneumonitis because the infection causes inflammation. Get useful, helpful and relevant health + wellness information. These antigens can include infectious organisms in mouldy hay or contaminated hot tubs, proteins from animals (such as pigeons), or tiny chemicals used in … Farmers and bird keepers are most frequently affected by this desease. Hypersensitivity pneumonitis (HP), also known as extrinsic allergic alveolitis, is one of the most common interstitial lung diseases (ILDs) 1,2.This particular ILD is characterized by exposure to an inhaled inciting antigen that leads to a host immunologic reaction determining … Bronchoscopy may be helpful in both doing a washing and pinching small biopsies during the procedure. Chest 2008;134(1):133–138. Methotrexate‐induced pneumonitis (MTX‐P) is rare and life threatening, and a number of possible risk factors have been suggested but none are consistent between studies. For people living with chronic hypersensitivity pneumonitis, it is very important to take care of your overall health. Hypersensitivity pneumonitis is a rare, interstitial lung disease (ILD) that affects only 2-3 people in 100,000 each year. Hypersensitivity pneumonitis (HP), or extrinsic allergic alveolitis, is an inflammatory syndrome of the lung caused by repetitive inhalation of antigenic agents in a susceptible host. During the physical exam, your doctor will use a stethoscope to listen carefully to your lungs while you breathe. Hypersensitivity pneumonitis usually occurs in people who work in places where there are high levels of organic dusts, fungus, or molds. However, it can cause permanent scarring and lung damage if you don’t catch it early enough. In general, symptoms of acute, or sudden, HP last between 12 hours and several days. Hanak V, Golbin JM, Hartman TE, Ryu JH. Hypersensitivity pneumonitis (HP), or extrinsic allergic alveolitis, is an inflammatory syndrome of the lung caused by repetitive inhalation of antigenic agents in a susceptible host. The syndrome varies in intensity, clinical presentation, and natural history depending on the inciting agent. We compare survival time and pulmonary function trajectory in patients with HP and IPF by radiologic phenotype. Over time, some people with chronic hypersensitivity pneumonitis develop clubbing of fingers and toes and irreversible pulmonary … For more severe cases, taking medications like corticosteroids often reverses the inflammation. Accessed 8/13/2018. Hypersensitivity pneumonitis is caused by an allergy to certain dusts (called allergens) that you breathe in, or inhale. Stem Cells, Familial IPF, Flying, FAQ: GERD, Fatigue & Environmental Exposure, FAQ: How to Travel to Your Doctor’s Office with Oxygen, FAQ’s: Alcohol, Clinical Trials, Pulmonary Function Testing, Healthy Holiday Season Habits with Pulmonary Fibrosis, Pulmonary Fibrosis and Gastro-Esophageal Reflux: 2019 Update, Frustrated with Poor Service from Medical Equipment Providers, Pulmonary Fibrosis and Pulmonary Hypertension – a New Treatment Option, Idiopathic Pulmonary Fibrosis Treatment Options, Research, Life Expectancy & Prognosis for Pulmonary Fibrosis. 2. This includes staying up-to-date with your vaccinations, eating a healthy diet and exercising regularly. Hypersensitivity pneumonitis (HP), or extrinsic allergic alveolitis, is an inflammatory syndrome of the lung caused by repetitive inhalation of antigenic agents in a susceptible host. These occupations include: Other activities that expose you to allergens can increase your likelihood of developing HP. 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